Analytical Data
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Gene name
LRRC15
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简介
LRRC15 protein actively modulates SARS-CoV-2 infectivity by directly interacting with the spike protein, inhibiting ACE2(+) cell infection. While not an entry receptor, LRRC15, expressed on nearby cells, sequesters virions, and its direct interaction with the spike protein's RBD domain leads to virion sequestration at the cell surface. LRRC15 Protein, Human (HEK293, Fc) is the recombinant human-derived LRRC15 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Leucine-rich repeat-containing protein 15; hLib; LRRC15; LIB
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TF66-1
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Expression Region
Y22-G538
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AA Sequence
YHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSG
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Protein Length
Extracellular Domain
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Molecular Weight
90-120 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LRRC15 (Leucine-Rich Repeat Containing 15) is a member of the leucine-rich repeat (LRR) protein family, which plays crucial roles in mediating various biological processes, including cell signaling, development, and immune responses. Recent studies have highlighted LRRC15's involvement in fibrosis and tumorigenesis, particularly in the tumor microenvironment where it appears to play a role in modulating immune cell behaviors. The protein is predominantly expressed in fibroblasts and has been associated with a variety of cancers, suggesting a potential role in promoting tumor progression through interactions with the extracellular matrix and immune cells. Given these implications, researchers are focused on characterizing the structure and function of LRRC15 to better understand its mechanisms and therapeutic potential. Recombinant LRRC15 proteins are being produced to facilitate these studies, allowing for the examination of its interactions with other biomolecules and its effects on cell behavior. This research is crucial for developing novel therapeutic strategies targeting LRRC15, potentially leading to new treatments for fibrotic diseases and cancers where LRRC15 is implicated. Understanding LRRC15's role in the tumor microenvironment could provide insights into the regulatory networks governing tumor-stroma interactions and immune evasion, offering promising avenues for intervention in malignancies.
