Analytical Data
-
Gene name
TSC22/TSC22D1
-
简介
TSC22D1 Protein, a positive modulator of cell death during mammary gland involution in response to TGFB3, forms a heterodimer with TSC22D4/THG1. Its interactions with histone H1-2 and GNL3 underscore TSC22D1's versatile role in molecular processes, emphasizing its potential significance in various cellular contexts. TSC22/TSC22D1 Protein, Human (His) is the recombinant human-derived TSC22/TSC22D1 protein, expressed by E. coli , with N-His labeled tag.
- Application
-
Alternative Names
TSC22 domain family protein 1; Cerebral protein 2; KIAA1994; TGFB1I4
-
Species
Human
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q15714-2
-
Expression Region
M1-A144
-
Protein Length
Full Length of Isoform-2
-
Molecular Weight
19-20 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TSC22/TSC22D1 is a member of the TSC22 family of proteins, which play significant roles in various cellular processes, including immune responses, cell differentiation, and stress responses. Originally identified as a gene induced during T cell activation, TSC22D1 has garnered attention for its regulatory functions in inflammatory diseases, autoimmune conditions, and cancer. Research has shown that TSC22D1 acts as a transcriptional repressor, modulating the expression of genes associated with inflammatory pathways, thereby influencing the balance between pro-inflammatory and anti-inflammatory signals. Furthermore, its expression levels are closely tied to various cellular contexts, highlighting its potential as a therapeutic target. Understanding the precise mechanisms of TSC22D1 function can provide insights into its role in cellular homeostasis and disease pathology, making it a crucial subject of study in molecular biology and therapeutic development. Moreover, recombinant TSC22D1 protein can be utilized in various assays and experimental setups to elucidate its functional properties and interactions with other biomolecules, underscoring the importance of this protein in both basic and applied research.
