Analytical Data
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基因名
IL-1 beta
- Application
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别名
IL1-B; IL1-Beta; IL1F2; IL-1β; Interleukin-1 Family Member 2; Catabolin
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01584
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表达区间
Ala117~Ser269
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蛋白长度
Partial
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分子量
33.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
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Protein Description
Interleukin-1 beta (IL-1β) is a pro-inflammatory cytokine that plays a crucial role in the immune response and inflammatory processes. Its dysregulation is implicated in various pathological conditions, including autoimmune diseases, chronic inflammatory disorders, and even certain cancers. IL-1β is primarily produced by activated macrophages and is known to influence the activity of various immune cells, promoting the expression of other pro-inflammatory cytokines and mediators. The research surrounding recombinant IL-1β protein focuses on understanding its structure, function, and the signaling pathways it activates. Recombinant forms of IL-1β are utilized in experimental therapies and investigational studies to explore their potential in treating diseases characterized by excessive inflammation. Furthermore, advancements in recombinant DNA technology have allowed for the production of high-purity IL-1β, facilitating rigorous studies of its biological activities and therapeutic applications. Researchers are particularly interested in its role as a therapeutic target to mitigate chronic inflammatory conditions, assessing its use in both in vitro and in vivo models. Overall, the study of IL-1β recombinant protein is vital for elucidating its mechanisms in inflammation and exploring novel therapeutic interventions to modulate immune responses in various diseases.
