Analytical Data
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基因名
SMR3B
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简介
SMR3B Protein is an important oncogenic driver that promotes cancer progression and metastasis. SMR3B overexpression in multiple cancers has pleiotropic effects, causing cells to acquire hallmark traits such as sustained proliferative signaling, replicative immortality, genome instability and mutation, resistance to cell death, angiogenesis etc. In addition, up-regulation of SMR3B activates the Src kinase, which initiates a number of signal pathways culminating in the phosphorylation of ERK1/2, STAT3, and p130. SMR3B Protein, Human (HEK293, His) is the recombinant human-derived SMR3B protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Submaxillary gland androgen-regulated protein 3B; PBII; PRL3; PROL3
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P02814
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表达区间
Q23-P79
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蛋白长度
Full Length of Mature Protein
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分子量
9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The SMR3B protein, a member of the small monomeric GTPase family, has garnered attention due to its role in various cellular processes and potential implications in human diseases. Research into SMR3B has revealed its involvement in signaling pathways that regulate cell growth, differentiation, and stress responses, making it a target of interest for both basic and applied research. As a reasearch subject, it is particularly relevant in the context of understanding its structural and functional characteristics through recombinant protein expression techniques. The ability to produce SMR3B as a recombinant protein allows scientists to study its biochemical properties, molecular interactions, and cellular functions in a controlled laboratory setting. Moreover, elucidating the structure-function relationship of SMR3B through techniques such as X-ray crystallography or nuclear magnetic resonance (NMR) can provide insights into its mechanism of action and the pathways it influences. This research is particularly significant in the ongoing effort to discover novel therapeutic targets for diseases where SMR3B may play a pivotal role, including cancer and neurodegenerative disorders. Given the complexity of its interactions and the challenges inherent in studying protein dynamics in vivo, the recombinant production of SMR3B is a crucial step in advancing our understanding of its biology and potential as a therapeutic target.
