Analytical Data
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Gene name
SMR3B
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简介
SMR3B Protein is an important oncogenic driver that promotes cancer progression and metastasis. SMR3B overexpression in multiple cancers has pleiotropic effects, causing cells to acquire hallmark traits such as sustained proliferative signaling, replicative immortality, genome instability and mutation, resistance to cell death, angiogenesis etc. In addition, up-regulation of SMR3B activates the Src kinase, which initiates a number of signal pathways culminating in the phosphorylation of ERK1/2, STAT3, and p130. SMR3B Protein, Human (HEK293, His) is the recombinant human-derived SMR3B protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Submaxillary gland androgen-regulated protein 3B; PBII; PRL3; PROL3
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P02814
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Expression Region
Q23-P79
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Protein Length
Full Length of Mature Protein
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Molecular Weight
9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The SMR3B protein, a member of the small monomeric GTPase family, has garnered attention due to its role in various cellular processes and potential implications in human diseases. Research into SMR3B has revealed its involvement in signaling pathways that regulate cell growth, differentiation, and stress responses, making it a target of interest for both basic and applied research. As a reasearch subject, it is particularly relevant in the context of understanding its structural and functional characteristics through recombinant protein expression techniques. The ability to produce SMR3B as a recombinant protein allows scientists to study its biochemical properties, molecular interactions, and cellular functions in a controlled laboratory setting. Moreover, elucidating the structure-function relationship of SMR3B through techniques such as X-ray crystallography or nuclear magnetic resonance (NMR) can provide insights into its mechanism of action and the pathways it influences. This research is particularly significant in the ongoing effort to discover novel therapeutic targets for diseases where SMR3B may play a pivotal role, including cancer and neurodegenerative disorders. Given the complexity of its interactions and the challenges inherent in studying protein dynamics in vivo, the recombinant production of SMR3B is a crucial step in advancing our understanding of its biology and potential as a therapeutic target.
