Analytical Data
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Gene name
Endoglycan/PODXL2
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简介
The endocan/PODXL2 protein serves as a ligand for angioselectin, enabling leukocytes to rapidly roll on the vascular surface through high-affinity divalent cation-dependent interactions with E-, P-, and L-selectin. Through disulfide bonds, the protein forms homodimers and interacts with specific selectins, including SELL, SELE, and SELP. Endoglycan/PODXL2 Protein, Human (HEK293, His) is the recombinant human-derived Endoglycan/PODXL2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Endoglycan; PODLX2; brain-1; BRN1; EG; oct-8; OTF8; UNQ1861/PRO3742
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Species
Human
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NZ53-1
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Expression Region
G33-T500
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Protein Length
Extracellular Domain
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Molecular Weight
70-115 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Endoglycan, also known as PODXL2, is a member of the Podocalyxin-like family of glycoproteins, which are primarily expressed in endothelial cells and play a crucial role in cellular processes such as migration, adhesion, and signaling. Researchers have identified Endoglycan as a key player in various physiological and pathological conditions, including cancer progression, inflammation, and organ development. Its unique structure, characterized by a heavily glycosylated extracellular domain, facilitates interactions with the extracellular matrix and other cell types, making it essential for maintaining vascular integrity and cell behavior. Given its involvement in significant biological processes and its potential as a biomarker for certain diseases, the production of recombinant Endoglycan protein has garnered interest for both basic research and therapeutic applications. The ability to produce this protein in suitable expression systems facilitates studies into its functional properties, molecular interactions, and potential use in targeted therapies. As researchers delve into the multifaceted roles of Endoglycan in health and disease, understanding its biochemical characteristics and pathways may provide insights into novel therapeutic approaches for conditions where this glycoprotein is implicated. This ongoing research not only sheds light on fundamental cellular mechanisms but also paves the way for innovative strategies in regenerative medicine and cancer therapy, wherein modulation of Endoglycan's activity could lead to improved patient outcomes.
