Analytical Data
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Gene name
CASP7
- Application
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Alternative Names
CMH1; ICE-LAP3; MCH3; Caspase 7 Apoptosis-Related Cysteine Peptidase; Cysteine Aspartate Protease 7; Cysteinyl Aspartate Specific Proteinases 7
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P55210
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Expression Region
Ala24~Asp198
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Molecular Weight
23kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CASP7, or Caspase-7, is a cysteine protease that plays a crucial role in the execution phase of apoptosis, the programmed cell death process. As a member of the caspase family, CASP7 is involved in the cleavage of various substrates, leading to cellular differentiation, inflammation, and apoptosis. Its activation is a key event in apoptotic signaling pathways and has been linked to various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions. The study of CASP7 recombinant protein is significant for understanding its functional mechanisms and regulatory pathways in apoptosis. Researchers aim to produce recombinant CASP7 in heterologous systems to study its enzymatic activity, substrate specificity, and interactions with other apoptotic regulators. This knowledge is critical for developing therapeutic strategies targeting apoptosis dysregulation in diseases. Additionally, elucidating the structural properties of CASP7 through recombinant expression can aid in drug design and the discovery of selective inhibitors that may have potential applications in cancer treatment. The growing interest in apoptosis as a therapeutic target underscores the importance of CASP7 research, as understanding its role in cellular processes can lead to innovative cancer therapies and interventions for other apoptosis-related diseases.
