Analytical Data
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Gene name
IRF1
- Application
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Alternative Names
Interferon regulatory factor 1; Interferon regulatory factor 1 isoform +I9; Interferon regulatory factor 1 isoform d78; Interferon regulatory factor 1 isoform delta4; Interferon regulatory factor 1 isoform delta7; IRF 1; IRF-1; IRF1; IRF1_HUMAN; MAR; MAR1
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Species
Human
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Source
Baculovirus
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Tag
N- His & C- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P10914
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Expression Region
1-325aa
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Molecular Weight
65.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IRF1 (Interferon Regulatory Factor 1) is a crucial transcription factor that plays a significant role in the immune response, particularly in the regulation of interferon and inflammatory gene expression. It is involved in various biological processes, including cell proliferation, apoptosis, and differentiation, thereby influencing both innate and adaptive immunity. Research on IRF1 has garnered attention due to its dual role in regulating immune responses and its potential implications in cancer, autoimmune diseases, and infectious diseases. The recombinant protein form of IRF1 is particularly valuable for in-depth studies, as it allows for the investigation of its functional properties, interaction with other proteins, and its role in signaling pathways. By producing IRF1 as a recombinant protein, researchers can explore its structural characteristics, binding affinities, and effects on target genes in various cellular contexts. This knowledge is vital for developing therapeutic strategies that harness the immune-modulating capabilities of IRF1 and could lead to novel approaches in cancer immunotherapy and treatments for immune-related disorders. The ongoing exploration of IRF1 and its recombinant protein forms continues to reveal intricate details about its mechanisms of action, thus highlighting its relevance in both basic and applied biomedical research.
