Analytical Data
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Gene name
GBA3
- Application
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Alternative Names
Cytosolic beta-glucosidase-like protein 1
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H227
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Expression Region
1-162aa
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Molecular Weight
45.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GBA3, or glucocerebrosidase 3, is an enzyme that plays a significant role in the lysosomal degradation of glucocerebrosides, crucial for cellular lipid metabolism. Abnormal function or mutations in GBA genes, particularly GBA1, are primarily associated with Gaucher's disease, whereas GBA3's role has been less understood yet holds potential importance in various pathophysiological conditions. Recent studies have suggested that GBA3 may have a regulatory role in immune response and neurodegeneration, indicating its potential impact on diseases like Parkinson’s. The study of recombinant GBA3 proteins is vital for elucidating its biochemical functions and interactions, as well as for exploring its therapeutic potentials. Understanding the structural and functional characteristics of GBA3 could offer insights into enzyme replacement therapies and other interventions for related disorders. This research is particularly relevant given the rising interest in gene therapy and enzyme modulation therapies, which hold promise for treating lysosomal storage diseases and neurodegenerative disorders. Overall, the investigation of GBA3 recombinant proteins is critical for uncovering their biological roles and advancing therapeutic strategies in the context of cellular dysfunctions linked to lipid metabolism and neuroinflammation.
