Analytical Data
-
Gene name
SLC4A4
- Application
-
Alternative Names
NBC; NBC1; NBCE1
-
Species
Human
-
Source
HEK293
-
Tag
Strep;His;GFP
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9Y6R1-1
-
Expression Region
M1-C1079
-
Protein Length
Full Length of Isoform-1
-
Molecular Weight
151.5 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC4A4, a member of the solute carrier family, is primarily known for encoding the electrogenic sodium bicarbonate cotransporter NBCe1, which plays a crucial role in acid-base balance and bicarbonate homeostasis in various tissues, particularly in the kidneys and central nervous system. Mutations in the SLC4A4 gene are associated with several disorders, including proximal renal tubular acidosis and a range of neurological conditions, highlighting its significance in human health. The interest in SLC4A4 recombinant protein research stems from its potential applications in understanding disease mechanisms, developing targeted therapies, and elucidating its physiological functions. Investigating the structure and function of SLC4A4 through recombinant protein studies enables researchers to explore its transport mechanisms, regulatory pathways, and interactions with other proteins. Moreover, the ability to produce and purify SLC4A4 as a recombinant protein allows for functional assays and structural analyses, offering insights into its role in bicarbonate transport and its implications for related pathologies. Thus, this research not only expands our fundamental understanding of the SLC4A4 transporter but also paves the way for innovative therapeutic strategies for conditions linked to its dysregulation.
