Analytical Data
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Gene name
CNTFR alpha
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简介
The CNTFR alpha protein is essential for binding to ciliary neurotrophic factor (CNTF), ensuring receptor specificity through its alpha subunit. It forms a heterotrimeric complex with LIFR and IL6ST to form a functional receptor. CNTFR alpha Protein, Rat (sf9, His) is the recombinant rat-derived CNTFR alpha protein, expressed by Sf9 insect cells , with C-His labeled tag.
- Application
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Alternative Names
Ciliary neurotrophic factor receptor subunit alpha; CNTFR-alpha
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Species
Rat
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Source
Baculovirus
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q08406
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Expression Region
Q23-P346
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Protein Length
Partial
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Molecular Weight
48 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CNTFR (Ciliary Neurotrophic Factor Receptor) alpha is a critical component in the signaling pathways of neurotrophic factors, playing an essential role in the survival and differentiation of neurons. The research surrounding CNTFR alpha has gained momentum due to its importance in neurological health and disease. This receptor is known to modulate various biological processes, including neuronal development and regeneration, making it a promising target for therapeutic interventions in conditions such as neurodegenerative diseases and nerve injuries. The elucidation of its structure and function has also facilitated the development of recombinant proteins, which serve as valuable tools in studying CNTFR alpha’s interactions with ciliary neurotrophic factor (CNTF) and other ligands. By analyzing these interactions in the context of cellular models, researchers aim to uncover the underlying mechanisms of synaptic plasticity and neuroprotection that could lead to novel drug discoveries. Additionally, the manipulation of CNTFR alpha signaling pathways holds potential for enhancing neurogenic therapies and supporting nerve repair processes. As such, the study of CNTFR alpha recombinant proteins not only deepens our understanding of neuronal biology but also opens up new avenues for innovative clinical applications in treating neurological disorders.
