Analytical Data
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基因名
FGFR-1
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简介
The FGFR-1 protein is a tyrosine-protein kinase receptor for fibroblast growth factors that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFR-1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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生物活性
Measured by its ability to inhibit FGF acidic-dependent proliferation of NIH 3T3 mouse fibroblast cells. The ED50 for this effect is 28.13ng/mL, corresponding to a specific activity is 35549.2357 Unit/mg. Measured by its ability to inhibit FGF acidic-dependent proliferation of NIH 3T3 mouse fibroblast cells.The ED50 for this effect is 28.13ng/mL, corresponding to a specific activity is 35549.2357 Unit/mg.
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别名
Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; HBGFR
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种属
Mouse
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P16092
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表达区间
R22-E376
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氨基酸序列
RPAPTLPEQAQPWGVPVEVESLLVHPGDLLQLRCRLRDDVQSINWLRDGVQLVESNRTRITGEEVEVRDSIPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRRPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLE
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蛋白长度
Extracellular Domain
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分子量
60-80 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fibroblast growth factor receptor 1 (FGFR-1) is a critical receptor in the signaling pathways that regulate various biological processes, including cell proliferation, differentiation, and survival. Its dysregulation has been implicated in a variety of pathological conditions, notably cancer and skeletal disorders. Researchers have observed that mutations, amplifications, or overexpression of FGFR-1 can lead to tumorigenesis, making it a potential biomarker and therapeutic target in oncology. In this context, the generation of recombinant FGFR-1 protein has garnered significant attention, facilitating detailed studies of its structure and function. Such recombinant proteins allow for the exploration of FGFR-1's interactions with its ligands and downstream signaling molecules, thus providing insights into its role in normal physiology and disease states. Furthermore, understanding the structural aspects of FGFR-1 through recombinant technology is crucial for the development of FGFR-targeted therapies. This includes the design of small-molecule inhibitors or monoclonal antibodies aimed at blocking this receptor’s activity in malignancies characterized by FGFR-1 aberrations. Overall, research on FGFR-1 recombinant proteins is vital for elucidating the biological mechanisms underlying its function, paving the way for innovative therapeutic strategies to combat related diseases.
