Analytical Data
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Gene name
MHCDQb1
- Application
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Alternative Names
HLA-DQB1; HLADQb1; CELIAC1; HLA-DQB; IDDM1; HLA Class II Histocompatibility Antigen,DQ Beta 1 Chain
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Species
Human
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Source
E. coli
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Tag
N-6His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P01920
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Expression Region
33~230aa
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Molecular Weight
29kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
MHCDQb1, a recombinant protein derived from the major histocompatibility complex (MHC) class II molecule, plays a critical role in the adaptive immune response by presenting peptide fragments to CD4+ T cells. Understanding its structure and function is essential for advancing therapeutic strategies in autoimmune diseases, cancer immunotherapy, and vaccine development. Research into MHCDQb1 focuses on its capacity to bind diverse peptide antigens, which influences T cell activation and subsequent immune responses. Moreover, studying the interactions between MHCDQb1 and T cell receptors can provide insights into the mechanisms of T cell recognition and specificity. This protein's characterization through techniques such as X-ray crystallography and mass spectrometry is pivotal for elucidating its conformational dynamics and binding affinities. Additionally, recombinant production of MHCDQb1 enables the exploration of its functionalities in various biological assays, which may lead to the identification of novel therapeutic targets and enhance our understanding of immune system regulation. The ongoing research surrounding MHCDQb1 holds promise for improving clinical outcomes in diseases characterized by aberrant immune responses.
