Analytical Data
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基因名
CCL4
- Application
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别名
G-26 T-lymphocyte-secreted protein, Lymphocyte activation gene 1 protein, LAG-1, MIP-1-beta1-69,
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 96% as determined by SDS-PAGE.
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蛋白编号
P13236
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表达区间
24-92aa
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蛋白长度
Partial
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分子量
7.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCL4 (Chemokine C-C motif ligand 4), also known as MIP-1β (macrophage inflammatory protein-1 beta), is an important chemokine involved in immune responses. It plays a significant role in the recruitment and activation of immune cells, particularly T cells and macrophages, to sites of inflammation and infection. Research on CCL4 has gained momentum due to its involvement in various pathological conditions, including autoimmune diseases, cancer, and viral infections. The understanding of CCL4's function is critical for developing therapeutic strategies aimed at modulating immune responses. Recombinant CCL4 proteins have been developed for experimental and therapeutic purposes, facilitating the investigation of its roles in immune signaling pathways. The study of CCL4's structure and function is essential in elucidating its interactions with specific receptors, such as CCR5, which is a co-receptor for HIV entry into host cells. Furthermore, recombinant CCL4 is utilized in assays to assess its effects on leukocyte migration, proliferation, and activation, offering insights into its potential as a therapeutic target. Given its multifunctional properties in the immune system, CCL4 continues to be a subject of intense study, with the aim of leveraging its biological activities to enhance vaccine efficacy, improve anti-tumor responses, and develop novel therapies for various diseases.
