Analytical Data
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基因名
MCP-2/CCL8
- Application
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别名
HC14Monocyte chemoattractant protein 2Monocyte chemotactic protein 2 ;MCP-2Small-inducible cytokine A8
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种属
Human
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表达系统
Yeast
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P80075
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表达区间
24-99aa
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蛋白长度
Partial
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分子量
10.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MCP-2, also known as CCL8, is a member of the CC chemokine family, playing a crucial role in immune response and inflammation by acting as a chemotactic factor for monocytes, basophils, and lymphocytes. Its significance in various pathological conditions, such as chronic inflammatory diseases, cancer, and autoimmune disorders, has sparked interest in understanding its biological functions and underlying mechanisms. Research has demonstrated that MCP-2/CCL8 is involved in promoting angiogenesis, modulating immune cell trafficking, and influencing cytokine production, which can have pathological implications. The availability of recombinant MCP-2/CCL8 protein allows researchers to investigate its role in various cellular assays and animal models, facilitating the exploration of potential therapeutic strategies targeting MCP-2/CCL8 signaling pathways. These studies aim to elucidate the molecular interactions and pathways influenced by MCP-2/CCL8, providing insights into its contributions to disease progression and highlighting its potential as a therapeutic target. The recombinant protein can also be used in drug discovery efforts to develop molecules that inhibit its action, thus potentially ameliorating diseases associated with its overexpression. Overall, the study of recombinant MCP-2/CCL8 protein is pivotal not only for advancing our understanding of immune regulation but also for developing novel therapeutic approaches for managing inflammation-related disorders.
