Analytical Data
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Gene name
PCDHb16
- Application
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Alternative Names
PCDHB8a; PCDH3X; PCDH-BETA16; ME1; Cadherin ME1; Protocadherin-3x; PCDHbeta 16
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NRJ7
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Expression Region
Val35~Val347
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Molecular Weight
39kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PCDHb16, a member of the protocadherin family, has garnered interest in recent years due to its potential roles in neural development and cell signaling. Protocadherins are known to be crucial for mediating cellular interactions and establishing specific neuronal connections in the brain. PCDHb16, in particular, is implicated in the modulation of synaptic functions and may play a key role in processes related to cell adhesion, neurite outgrowth, and the formation of neuronal networks. Investigating the recombinant protein of PCDHb16 is vital for understanding its structural and functional properties, which can shed light on its involvement in synaptic plasticity and neurodevelopmental disorders. The study of PCDHb16 may also provide insights into the mechanisms underlying various neurological conditions, as perturbations in protocadherin expression or function have been associated with developmental disruptions and psychiatric disorders. Furthermore, characterizing PCDHb16 as a recombinant protein allows for controlled experiments to elucidate its biological activities and interactions with other proteins. This understanding could lead to potential therapeutic strategies targeting PCDHb16-related pathways in the treatment of neurodevelopmental and neurodegenerative diseases, emphasizing the significance of this research in both basic neuroscience and clinical applications.
