Analytical Data
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Gene name
PCDH15
- Application
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Alternative Names
USH1F; DFNB23; CDHR15; Deafness,Autosomal Recessive 23; Cadherin-Related Family Member 15
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99PJ1
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Expression Region
Pro45~Phe270
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Molecular Weight
34kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PCDH15 (protocadherin 15) is a member of the protocadherin family, which plays crucial roles in cell adhesion and signaling, particularly in the auditory and visual systems. Mutations in the PCDH15 gene are linked to various forms of hereditary hearing loss and other sensory deficits, highlighting its significance in sensory cell function and development. Researchers have focused on generating recombinant PCDH15 proteins to elucidate their structural properties and functional mechanisms, providing insights into how these proteins mediate cell-cell interactions and contribute to the integrity of sensory tissues. Understanding the dynamics of PCDH15 through recombinant forms can pave the way for developing therapeutic interventions for genetic disorders associated with its malfunction. By studying the protein's interactions with other cellular components and its role in the formation of sensory synapses, scientists aim to uncover new pathways involved in auditory and visual processing, ultimately enhancing our knowledge of sensory biology and potential treatment strategies for related disorders. This research is pivotal for both basic science and clinical applications, as it informs approaches to restore or enhance sensory function in patients affected by PCDH15 mutations.
