Analytical Data
-
基因名
BIRC6
- Application
-
别名
BRUCE; Apollon; BIR repeat-containing ubiquitin-conjugating enzyme; Ubiquitin-conjugating BIR domain enzyme apollon
-
种属
Human
-
表达系统
E. coli
-
标签
N-His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q9NR09
-
表达区间
Arg4576~Leu4857
-
分子量
40kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BIRC6, a member of the inhibitors of apoptosis (IAP) gene family, plays a critical role in regulating cellular apoptosis and ensuring cell survival under various stress conditions. Research has shown that BIRC6 is overexpressed in several types of cancer, including ovarian and breast cancers, where it contributes to tumor progression by inhibiting caspases, the key enzymes responsible for mediating apoptosis. Due to its pro-survival function, BIRC6 has become a potential target for therapeutic intervention, particularly in cancer treatments aimed at restoring apoptotic pathways to induce cell death in malignant cells. The production of recombinant BIRC6 protein is essential for understanding its structure-function relationships and interactions with other cellular proteins. This knowledge can aid in the development of small molecules or antibodies that can disrupt BIRC6's interaction with caspases or other apoptotic factors, thereby enhancing the efficacy of existing chemotherapy treatments. Additionally, studying the post-translational modifications of BIRC6 can provide insights into its regulatory mechanisms and biological significance in both normal and pathological conditions. The recombinant BIRC6 protein serves as a valuable tool in elucidating these mechanisms and potentially identifying novel therapeutic strategies targeting aberrant apoptosis in cancers. Overall, the investigation of BIRC6 through recombinant protein technology highlights its significance in cancer biology and opens new avenues for targeted therapies aimed at overcoming apoptosis resistance in tumor cells.












