Analytical Data
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Gene name
BANK1
- Application
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Alternative Names
BANK1B-cell scaffold protein with ankyrin repeats
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Species
Human
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Source
Yeast
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NDB2
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Expression Region
1-785aa
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Molecular Weight
91.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BANK1 (B-cell scaffold protein with ankyrin repeats 1) is an essential adaptor protein involved in various signaling pathways, particularly in B-cell signaling and immune responses. Research has indicated that BANK1 plays a critical role in the development and activation of B-cells, influencing processes such as proliferation, differentiation, and antibody production. It contains multiple protein-protein interaction domains that facilitate its role as a scaffold, bringing together different signaling molecules to orchestrate cellular responses upon antigen receptor engagement. Notably, studies have linked BANK1 to several autoimmune conditions, including systemic lupus erythematosus (SLE), highlighting its potential as a target for therapeutic interventions. Given its pivotal role in immunity and disease, understanding the structure and function of BANK1 through recombinant protein studies can provide insights into its mechanisms of action, identify critical interaction partners, and uncover new pathways involved in immune regulation and pathology. The ongoing research aims to elucidate the precise molecular functions of BANK1 and leverage this knowledge for the development of novel strategies to manipulate immune responses in diseases where BANK1 is implicated.
