Analytical Data
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基因名
CDC73
- Application
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别名
HPT-JT; HRPT2; C1orf28; Parafibromin; Hyperparathyroidism 2 protein
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6P1J9
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表达区间
Arg232~Phe531
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分子量
38kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDC73, also known as cell division cycle 73, is an essential protein involved in various cellular processes, including transcription regulation and the maintenance of chromatin structure. It is part of the Paf1 complex, which is crucial for RNA polymerase II-mediated transcription elongation and is implicated in regulating gene expression. Research into CDC73 has gained prominence due to its association with hereditary paraganglioma and pheochromocytoma syndromes, where mutations in the CDC73 gene lead to tumorigenesis. The study of CDC73 also extends to understanding its role in the development of other cancers, such as renal and cervical cancers, reflecting its importance as a tumor suppressor. The recombinantly expressed CDC73 protein serves as a valuable tool for investigating its functions and interactions in vitro, providing insights into its molecular mechanisms and potential therapeutic targets. Current research is focused on elucidating the pathways influenced by CDC73, exploring its involvement in cellular signaling, and examining the effects of specific mutations on its functionality, thereby contributing to a deeper understanding of cancer biology and the development of targeted therapies.
