Analytical Data
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基因名
AKAP12
- Application
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别名
AKAP250; Gravin; A-kinase anchor protein 250 kDa; Myasthenia gravis autoantigen
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q02952
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表达区间
Pro1485~Ser1782
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分子量
56kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AKAP12, also known as A-kinase anchoring protein 12, is a member of the AKAP family of proteins that play crucial roles in cellular signaling by anchoring protein kinases to specific cellular locales. These proteins are involved in a multitude of cellular processes, including cell growth, differentiation, and apoptosis, through their interactions with various signaling molecules. The study of AKAP12 has garnered significant attention due to its implications in cancer biology and other diseases. Evidence suggests that AKAP12 functions as a tumor suppressor, with its downregulation or loss being associated with various malignancies, particularly in breast and prostate cancers. Researchers have identified that AKAP12 regulates important signaling pathways, including those mediated by cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA), which can influence cellular responses to external stimuli and stress. The recombinant expression of AKAP12 allows for the detailed study of its structural and functional properties, facilitating the understanding of its role in disease mechanisms. Additionally, exploring the therapeutic potential of targeting AKAP12 pathways could offer novel strategies for cancer treatment and other related disorders. Overall, the ongoing research on AKAP12 and its recombinant protein continues to shed light on its multifaceted roles in cellular signaling and its significance in health and disease.
