Analytical Data
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基因名
PGAM5
- Application
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生物活性
Human PGAM5 immobilized on CM5 Chip can bind LFHP-1c with an affinity constant of 425.8 nM as determined in a SPR assay. Human PGAM5 immobilized on CM5 Chip can bind LFHP-1c with an affinity constant of 425.8 nM as determined in a SPR assay.
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别名
Bcl-XL-binding protein v68; Phosphoglycerate mutase family member 5
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种属
Human
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表达系统
E. coli
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q96HS1-1
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表达区间
K30-S289
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蛋白长度
Partial
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分子量
31-40 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PGAM5 (Phosphoglycerate Mutase 5) is a member of the phosphoglycerate mutase family, implicated in various cellular processes, including metabolism and signaling. Research interest in PGAM5 has surged due to its pivotal role in regulating mitochondrial dynamics and apoptosis. It functions as a key player in the regulation of cell fate decisions, responding to cellular stress and helping maintain mitochondrial integrity. Dysregulation of PGAM5 has been linked to several diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. The recombinant protein form of PGAM5 offers a valuable tool for dissecting its functional mechanisms and interactions within cellular pathways. Additionally, the production of PGAM5 as a recombinant protein allows for detailed biochemical studies, including enzyme kinetics and structure-function analyses. Understanding PGAM5’s role at the molecular level is vital for developing targeted therapeutic strategies. As researchers strive to uncover the complexities of PGAM5's involvement in cellular processes, the recombinant protein serves as a crucial asset in elucidating its contributions to health and disease. This research opens avenues for potential interventions in various pathologies associated with mitochondrial dysfunction and highlights the importance of PGAM5 in cellular homeostasis.
