Analytical Data
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基因名
PDE12
- Application
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别名
2'-PDE; 2'-Phosphodiesterase; Mitochondrial deadenylase
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q3TIU4
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表达区间
Glu290~Val602
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分子量
39kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of PDE12 recombinant protein is situated at the intersection of molecular biology and biochemistry, focusing on the role of phosphodiesterases (PDEs) in cellular signaling pathways. PDE12, a member of the PDE family, is implicated in the hydrolysis of cyclic nucleotides, which are crucial for various physiological processes, including cell proliferation, differentiation, and apoptosis. Research indicates that alterations in PDE activity can lead to various diseases, including cancer and neurodegenerative disorders, making PDE12 a significant target for therapeutic interventions. Furthermore, understanding the structural and functional characteristics of PDE12 can provide insights into its regulatory mechanisms and potential as a drug target. Recombinant protein technology allows for the expression and purification of PDE12, enabling detailed studies of its enzymatic activity, inhibitor interactions, and overall role in cell signaling. As such, the investigation of PDE12 recombinant protein not only enhances our comprehension of PDE functions but also holds promise for the development of novel therapeutic strategies aimed at modulating cyclic nucleotide signaling in disease contexts.
