Analytical Data
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基因名
KCIP-1
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简介
KCIP-1 protein serves as the linker of TNFRSF1A/TNFR1 and mediates its interaction with FADD. Overexpression induces TNF-induced responses: apoptosis and NF-κ-B activation. KCIP-1 Protein, Mouse (P.pastoris, His, solution) is the recombinant mouse-derived KCIP-1 protein, expressed by P. pastoris , with N-6*His labeled tag.
- Application
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别名
Ywhab; 14-3-3 protein beta/alpha; Protein kinase C inhibitor protein 1; KCIP-1
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种属
Mouse
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表达系统
P. pastoris
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9CQV8-1
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表达区间
M1-N246
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氨基酸序列
MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICNDVLELLDKYLILNATQAESKVFYLKMKGDYFRYLSEVASGENKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDEGDAGEGEN
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蛋白长度
Full Length of Isoform-1
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分子量
33 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCIP-1, a novel recombinant protein, has emerged as a significant subject of research due to its potential implications in cellular processes and disease mechanisms. Identified as a member of a unique protein family, KCIP-1 has been implicated in regulating various biological pathways, including cell proliferation, differentiation, and apoptosis. Its distinct structural features, including specific domain arrangements, suggest potential interactions with a range of molecular partners, which could elucidate its functional roles in vivo. Recent studies have highlighted KCIP-1's involvement in oncogenesis, where its expression levels correlate with tumor progression and patient prognosis, underscoring its potential as a biomarker or therapeutic target. Moreover, the recombinant production of KCIP-1 has enabled detailed investigations into its biophysical properties and mechanisms of action, facilitating the exploration of its role in modulating signal transduction pathways and gene expression. Given the increasing interest in protein-based therapeutics, understanding KCIP-1's function and regulatory mechanisms may pave the way for novel intervention strategies in cancer and other diseases. Thus, ongoing research aims to clarify its biological significance and therapeutic potential, marking KCIP-1 as a critical focus in protein science and biomedical research.
