Analytical Data
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Gene name
AP1s1
- Application
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Alternative Names
AP19; CLAPS1; SIGMA1A; Clathrin-Associated/Assembly/Adaptor Protein,Small 1; Clathrin Coat Assembly Protein AP19; HA1 19 kDa; Golgi adaptor HA1/AP1 adaptin sigma-1A
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P61966
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Expression Region
Met1~Ala158
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Molecular Weight
24kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AP1S1, or adenylyl cyclase-associated protein 1S1, is a protein that has garnered attention in the fields of molecular biology and genetics due to its role in cellular processes such as clathrin-mediated endocytosis and intracellular trafficking. The protein is encoded by the AP1S1 gene, mutations in which have been linked to genetic disorders, particularly those affecting the immune system, such as immunodeficiency. The study of AP1S1 and its function within the AP-1 (adaptor protein complex 1) system is crucial for understanding how proteins are sorted and transported within cells. Research into AP1S1's structural and functional properties has led to insights into its interactions with other cellular components, shedding light on its role in maintaining cellular homeostasis and function. Furthermore, investigations into AP1S1 offer the potential for therapeutic developments aimed at correcting the cellular dysfunctions caused by AP1S1 mutations. Given the growing body of evidence highlighting the significance of AP1S1 in various physiological and pathological contexts, ongoing research is critical for unraveling its precise mechanisms of action and potential applications in disease treatment and prevention.
