Analytical Data
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Gene name
KAT2B
- Application
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Alternative Names
PCAF; P/CAF; GCN5; GCN5L; P300/CBP-Associated Factor; Histone acetyltransferase PCAF; Lysine acetyltransferase 2B
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92831
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Expression Region
Ala643~Lys832
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Molecular Weight
26kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KAT2B, also known as GCN5, is a member of the MYST family of histone acetyltransferases, playing a crucial role in the regulation of gene expression through histone acetylation. This protein is involved in various cellular processes, including transcriptional activation, DNA repair, and cell cycle progression. Dysregulation of KAT2B has been implicated in numerous diseases, including cancer and neurodegenerative disorders, making it a significant target for therapeutic intervention. Recent research has focused on the structural and functional characterization of KAT2B, along with the identification of its substrates and interacting partners. Recombinant KAT2B proteins are essential for these studies, providing valuable insights into the enzyme's mechanisms and potential roles in disease. By producing KAT2B in a recombinant form, researchers can investigate its enzymatic activity, explore protein-protein interactions, and assess the effects of small molecules or inhibitors on its function. This research is vital for understanding how KAT2B contributes to cellular homeostasis and for developing novel strategies to modulate its activity in pathological conditions. As the field progresses, the elucidation of KAT2B's role in epigenetic regulation and its therapeutic potential continues to attract significant attention, highlighting the importance of recombinant protein research in unraveling the complexities of gene regulation.
