Analytical Data
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Gene name
STAG3
- Application
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Alternative Names
SCC3 homolog 3; Stromalin-3; Cohesin subunit SA-3
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UJ98
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Expression Region
Met1~Pro149
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Molecular Weight
51kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STAG3 (SYNORF 3), a member of the stromal antigen protein family, plays a crucial role in the process of meiosis, specifically in the formation and function of the synaptonemal complex during prophase I. This complex is essential for homologous chromosome pairing and recombination, which are critical for gamete production and genetic diversity. Research into STAG3 has revealed its involvement in various reproductive disorders, particularly those related to infertility and chromosomal abnormalities. Mutations or altered expression levels of STAG3 can lead to impaired meiotic progression, resulting in aneuploidy or infertility. Studies have also highlighted the potential of STAG3 as a biomarker for assessing fertility issues and as a target for therapeutic interventions. Furthermore, advancements in recombinant protein technology have allowed for the detailed study of STAG3’s structure and function, enabling scientists to explore its interaction with other meiotic proteins and its role in genetic regulation. The ongoing research into STAG3 not only enhances our understanding of meiosis and reproductive biology but also contributes to the development of diagnostic and therapeutic strategies for human infertility. Thus, STAG3 serves as a key protein of interest in both basic and applied biological research, with implications for reproductive health and genetic counseling.
