Analytical Data
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基因名
BMP-3
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简介
BMP-3 Protein, a TGF-beta superfamily member, crucially influences early skeletal formation and acts as a bone density negative regulator. It counteracts osteogenic BMPs, hindering osteoprogenitor differentiation. BMP-3 initiates signaling via ACVR2B, activating SMAD2-dependent and SMAD-independent pathways, including TAK1 and JNK. Structurally, it forms homodimers with disulfide bonds, interacting with ACVR2B to regulate functions. BMP-3 Protein, Human is the recombinant human-derived BMP-3 protein, expressed by E. coli , with tag free.
- Application
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别名
Bone Morphogenetic Protein 3; Osteogenin; Bone Morphogenetic Protein 3 (Osteogenic); Bone Morphogenetic Protein 3A; BMP-3A; BMP3A; BMP-3
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P12645
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表达区间
Q363-R472
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蛋白长度
Full Length of Mature Protein
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分子量
12 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BMP-3 (Bone Morphogenetic Protein 3) is a member of the transforming growth factor-beta (TGF-β) superfamily, primarily known for its role in bone and cartilage development. Research has highlighted BMP-3's unique function as an antagonist to other BMPs, particularly in regulating skeletal growth and homeostasis. Unlike other BMPs that promote osteogenesis, BMP-3 inhibits bone formation, offering insights into the intricate balance of signaling pathways involved in bone metabolism. The recombinant expression of BMP-3 protein in various systems has facilitated detailed studies on its functional properties, biological activities, and potential therapeutic applications. Recent advancements in biotechnology, such as genetic engineering and recombinant DNA technologies, have enabled scientists to produce BMP-3 in sufficient quantities for experimental use. This has paved the way for in-depth investigations into its mechanisms of action, as well as its implications in conditions like osteoporosis and osteoarthritis. Furthermore, the study of BMP-3 has garnered interest in tissue engineering and regenerative medicine, where understanding its antagonistic nature towards osteogenic differentiation could lead to novel strategies for managing bone-related disorders. As research continues to unravel the complexities of BMP-3 signaling pathways, the potential for developing targeted therapies utilizing BMP-3 or its pathways becomes increasingly promising. Hence, BMP-3 recombinant protein research not only contributes to our understanding of skeletal biology but also holds significant therapeutic potential for regenerative medicine applications.
