Analytical Data
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基因名
P-Selectin
- Application
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别名
CD62P; Selectin, Platelet; PSEL; GMP140; LECAM3; GRMP; GMRP; PADGEM; Leukocyte-endothelial cell adhesion molecule 3; Platelet activation dependent granule-external membrane
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种属
Pig
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q29097
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表达区间
Trp42~Tyr159
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分子量
17kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
P-Selectin, a cell adhesion molecule predominantly expressed on activated endothelial cells and platelets, plays a crucial role in the inflammatory response and thrombosis. The protein is part of the selectin family, which facilitates the rolling of leukocytes on the endothelium during inflammation and tissue repair. Its interaction with specific carbohydrates on leukocytes initiates their recruitment to sites of injury or inflammation. Given its significant involvement in various pathological conditions, including cardiovascular diseases, autoimmune disorders, and cancer metastasis, P-Selectin has emerged as a promising therapeutic target. Researchers have focused on the development of recombinant P-Selectin proteins for studying its structure and function, as these proteins allow for detailed investigations into its binding kinetics and molecular interactions. Such studies are essential for understanding how P-Selectin mediates cell adhesion and signaling. Moreover, recombinant P-Selectin can serve as a basis for creating antagonists or inhibitors that might reduce unwanted inflammatory responses or thrombosis, thus paving the way for novel therapeutic strategies in treating diseases linked to P-Selectin activity. The ongoing research not only enhances the comprehension of P-Selectin's biological roles but also contributes to the potential development of targeted therapies that could improve patient outcomes in various inflammatory and thrombotic conditions.












