Analytical Data
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基因名
PIGR
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简介
PIGR proteins play a critical role in mediating the selective transcytosis of polymerized IgA and IgM across mucosal epithelial cells, which is critical for mucosal immunity. PIGR binds these immunoglobulins at the basolateral surface, forming a complex that is transported intracellularly and secreted apically. PIGR Protein, Human (G365S, HEK293, His) is the recombinant human-derived PIGR protein, expressed by HEK293 , with C-His labeled tag and G365S mutation.
- Application
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别名
Polymeric Immunoglobulin Receptor; Poly-Ig Receptor; PIGR
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01833
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表达区间
K19-R638, G365S
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蛋白长度
Extracellular Domain
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PIGR (Polymeric Immunoglobulin Receptor) is a crucial protein involved in the transport of immunoglobulin A (IgA) and immunoglobulin M (IgM) across epithelial cells, playing a vital role in mucosal immunity. Research into PIGR has gained momentum due to its significant implications in understanding immune responses, particularly in mucosal surfaces such as the gut, respiratory tract, and other secretory systems. Dysregulation of PIGR is associated with various diseases, including autoimmune disorders, inflammatory diseases, and certain types of cancer, making it an attractive target for therapeutic intervention. The recombinant version of PIGR allows for detailed studies on its structural and functional properties, enabling scientists to explore the mechanisms of antibody transportation and secretion. Furthermore, recombinant PIGR can be employed in the development of novel vaccines and immunotherapies, enhancing the effectiveness of immune responses. As researchers continue to unravel the complexity of PIGR interactions and its role in health and disease, the exploration of recombinant proteins holds promise for advancing our understanding of mucosal immunity and developing innovative strategies against mucosal pathogens.
