Analytical Data
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基因名
EPN1
- Application
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别名
EPS-15-Interacting Protein 1; EH domain-binding mitotic phosphoprotein
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y6I3
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表达区间
Pro279~Gly437
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分子量
41kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EPN1, or Epsin 1, is an important protein involved in various cellular processes, particularly in the endocytic pathway and membrane dynamics. This protein contains a highly conserved Epsin N-terminal Homology (ENTH) domain, which plays a crucial role in clathrin-mediated endocytosis. EPN1 is known to interact with clathrin and other proteins involved in vesicle formation, thus facilitating the internalization of receptors and nutrients into the cell. Research into EPN1's role has gained momentum due to its implications in several biological processes, including signal transduction, growth factor receptor recycling, and cellular response to stress. Furthermore, aberrant EPN1 function has been associated with various diseases, including cancer and neurodegenerative disorders, making it a potential target for therapeutic interventions. Understanding the structure and function of EPN1 at the molecular level can provide insights into its regulatory mechanisms and how its dysregulation could contribute to disease pathology. Recent studies emphasize the importance of EPN1 in modulating cellular signaling pathways and maintaining cellular homeostasis, underscoring the necessity for comprehensive research into its biochemical properties and functional roles in health and disease.
