Analytical Data
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基因名
MIP-3 beta/CCL19
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简介
The MIP-3 beta/CCL19 protein exhibits multifaceted effects affecting lymphocyte recycling, homing, and immune responses. It is involved in T cell trafficking in the thymus and guides T cells and B cells to secondary lymphoid organs by binding to CCR7. MIP-3 beta/CCL19 Protein, Human is the recombinant human-derived MIP-3 beta/CCL19 protein, expressed by E. coli , with tag free.
- Application
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生物活性
Measured by its ability to chemoattract Jurkat cells. The ED50 for this effect is 27.79 ng/mL, corresponding to a specific activity is 3.598×104 U/mg. Measured by its ability to chemoattract Jurkat cells. The ED50 for this effect is 27.79 ng/mL, corresponding to a specific activity is 3.598×104 U/mg.
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别名
Alternative macrophage activation-associated CC chemokine 1, CC chemokine PARC, Dendritic cell chemokine 1, DC-CK1, Macrophage inflammatory protein 4
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 95% as determined by reducing SDS-PAGE.
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蛋白编号
Q99731
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表达区间
G22-S98
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蛋白长度
Full Length of Mature Protein
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分子量
11 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MIP-3 beta, also known as CCL19, is a chemokine that plays a crucial role in the immune system by regulating the migration of immune cells, particularly lymphocytes, to sites of inflammation and lymphoid tissues. It primarily interacts with the CCR7 receptor, which is vital for the proper functioning of T cells and dendritic cells in immune responses. Research on MIP-3 beta/CCL19 has gained significant attention due to its potential applications in immunotherapy, vaccine development, and understanding autoimmune diseases. The interest in recombinant MIP-3 beta/CCL19 proteins has increased, as these proteins can be utilized to enhance immune responses or to study lymphocyte trafficking in various pathological conditions. By producing recombinant forms of CCL19, researchers aim to investigate its structural properties, understand its signaling mechanisms, and explore its therapeutic potential in enhancing immune responses or modulating inflammatory conditions. Furthermore, understanding the role of CCL19 in the tumor microenvironment may provide insights into cancer immunology and aid in developing novel cancer treatments. Overall, the study of recombinant MIP-3 beta/CCL19 is instrumental in advancing our knowledge of immune cell regulation and developing new strategies for immune modulation in various diseases.
