Analytical Data
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基因名
HIST1H1B
- Application
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别名
H1F5; H1.5; H1 Histone Family Member 5
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P16401
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表达区间
Ser2~Lys226
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分子量
52kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of histone proteins, particularly the HIST1H1B gene, has garnered significant attention due to its essential role in chromatin structure and function. HIST1H1B encodes a member of the histone H1 family, which is crucial for the compaction of DNA into higher-order structures, facilitating proper gene regulation and expression. Alterations in histone modifications and their dynamics have been implicated in various biological processes and diseases, including cancer. As a linker histone, HIST1H1B participates in stabilizing nucleosome interactions, influencing transcriptional repression and chromatin organization. Understanding the molecular mechanisms by which HIST1H1B and related histone proteins govern chromatin dynamics can provide insights into epigenetic regulation and potential therapeutic avenues for diseases associated with chromatin misregulation. Moreover, the recombinant expression and characterization of HIST1H1B provide a valuable tool for in vitro studies, enabling researchers to dissect its functional roles further and explore its potential as a biomarker or therapeutic target in oncology and other fields. This research is crucial not only for basic biology but also for developing novel strategies in epigenetic therapies.
