Analytical Data
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Gene name
Alpha-Fetoprotein
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简介
Alpha-Fetoprotein binds copper, nickel, and fatty acids, displaying particular affinity for bilirubin, albeit less efficiently than serum albumin. Its structural variations, including dimeric and trimeric forms, alongside the monomeric state, contribute to the protein's versatile functionality. This complexity in molecular interactions with diverse ligands underscores Alpha-Fetoprotein's significance in various physiological processes. Alpha-Fetoprotein Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Alpha-Fetoprotein protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
rHuAlpha-Fetoprotein, His; AFP; Alpha-Fetoprotein
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Species
Cynomolgus
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A0A2K5U7U0
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Expression Region
R19-V609
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Protein Length
Full Length of Mature Protein
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Molecular Weight
68-75 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Alpha-fetoprotein (AFP) is a glycoprotein typically produced by the fetal liver, yolk sac, and gastrointestinal tract, making it a key biomarker in prenatal screening. Its elevated levels in adults are associated with liver diseases, particularly hepatocellular carcinoma, as well as germ cell tumors. The recombinant production of AFP has gained significant attention in recent years due to its potential applications in diagnostics and therapeutics. Researchers have focused on developing recombinant AFP to improve the sensitivity and specificity of cancer detection and to explore its role in immunotherapy. By utilizing recombinant DNA technology, scientists can produce AFP in various expression systems, allowing for easier purification and modification. This approach not only enhances our understanding of AFP’s biological functions but also supports the development of AFP-targeted therapies and vaccines. Given the importance of AFP in clinical settings, ongoing studies aim to optimize its production and increase the efficacy of AFP-based interventions, ultimately contributing to the early diagnosis and treatment of liver and germ cell tumors.
