Analytical Data
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基因名
FITC-Labeled TPBG/5T4
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简介
TPBG/5T4 protein acts as an inhibitor of Wnt/β-catenin signaling, possibly by interacting indirectly with LRP6 and hindering Wnt3a-dependent LRP6 internalization. This means that TPBG/5T4 plays a crucial role in regulating the complex Wnt/β-catenin signaling pathway and exerts a regulatory influence on cellular responses related to this pathway. TPBG/5T4 Protein, Human (FITC, HEK293, His-Avi) is the recombinant human-derived TPBG/5T4 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Application
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别名
M6P1; 5T4AG; WAIF1; TPBG; 5T4
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13641-1
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表达区间
S32-S355
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蛋白长度
Extracellular Domain
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分子量
50-70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FITC-labeled TPBG/5T4 recombinant protein has garnered significant attention in cancer research due to its potential role in targeting tumors. 5T4 is a tumor-associated glycoprotein typically overexpressed in various malignancies, including solid tumors, making it a promising candidate for targeted therapy and diagnostics. TPBG, or trophoblast-derived protein, is known for its involvement in immune evasion in the tumor microenvironment. By labeling TPBG/5T4 recombinant proteins with fluorescein isothiocyanate (FITC), researchers can track their distribution and interactions in biological systems through fluorescence microscopy and flow cytometry. This approach facilitates the study of TPBG/5T4 interactions with immune cells and tumor tissues, helping to elucidate their roles in cancer progression and immunology. The use of FITC not only enhances the visualization of protein localization but also allows for quantitative analysis of receptor binding and cellular uptake, thereby contributing to the development of targeted therapies and diagnostic tools. Understanding the signaling pathways influenced by TPBG/5T4 may yield insights into novel therapeutic strategies aimed at inhibiting tumor growth and improving patient outcomes. This research underscores the importance of identifying specific tumor markers and exploring innovative methods for cancer treatment, paving the way for more effective and personalized approaches in oncology.
