Analytical Data
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Gene name
FOLR2
- Application
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Alternative Names
Folate receptor 2 Folate receptor, fetal/placental Placental folate-binding protein
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Species
Human
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Source
Baculovirus
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P14207
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Expression Region
19-230aa
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Molecular Weight
27.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FOLR2, or Folate Receptor 2, is a type of glycoprotein that plays a crucial role in the transport of folate into cells, a vital process for DNA synthesis, repair, and overall cellular proliferation. Its expression is notably elevated in certain cancer types, making it a potential biomarker for tumor identification and a target for targeted therapies. Research in recent years has focused on the development of recombinant FOLR2 proteins to investigate their structural and functional characteristics, as well as their interactions with folate and folate-conjugated drugs. Recombinant FOLR2 proteins offer a means to explore the receptor's role in cancer biology, enhance our understanding of folate metabolism in tumorigenesis, and deliver therapeutic agents specifically to FOLR2-expressing cells. The study of FOLR2 recombinant proteins is pivotal in the context of designing FOLR2-targeted therapeutics, such as antibody-drug conjugates and nanoparticle-based drug delivery systems, which aim to improve the efficacy and reduce the side effects of cancer treatments. The ongoing research into FOLR2 not only sheds light on its biological significance but also paves the way for the development of innovative cancer therapies that harness the receptor's unique properties for targeted treatment strategies.
