Analytical Data
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基因名
JAML/AMICA
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简介
JAML is a leukocyte plasma membrane transmembrane protein that critically regulates cell migration and activation by interacting with CXADR on neighboring cells. This interaction activates γ-δ T cells and induces downstream signaling through PI3 kinase and MAP kinase. JAML/AMICA Protein, Human (HEK293, His) is the recombinant human-derived JAML/AMICA protein, expressed by HEK293 , with C-His, C-6*His labeled tag.
- Application
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别名
Junctional adhesion molecule-like; JAML; AMICA1; CREA7-1
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86YT9-1
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表达区间
L20-L275
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氨基酸序列
LNDLNVSPPELTVHVGDSALMGCVFQSTEDKCIFKIDWTLSPGEHAKDEYVLYYYSNLSVPIGRFQNRVHLMGDILCNDGSLLLQDVQEADQGTYICEIRLKGESQVFKKAVVLHVLPEEPKELMVHVGGLIQMGCVFQSTEVKHVTKVEWIFSGRRAKEEIVFRYYHKLRMSVEYSQSWGHFQNRVNLVGDIFRNDGSIMLQGVRESDGGNYTCSIHLGNLVFKKTIVLHVSPEEPRTLVTPAALRPLVLGGNQL
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蛋白长度
Extracellular Domain
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分子量
39 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of JAML (Junctional Adhesion Molecule-Like) and AMICA (Adhesion Molecule Involved in Lymphocyte Adhesion) recombinant proteins is rooted in their significant roles in immunology and cellular adhesion processes. These proteins belong to the immunoglobulin superfamily and are primarily expressed in immune cells, where they facilitate interactions between leukocytes and endothelial cells. Understanding their structural and functional characteristics is crucial for elucidating their mechanisms in immune responses, particularly in processes such as lymphocyte migration, tissue infiltration, and inflammation. Recent research has highlighted their potential involvement in regulating immune cell trafficking and modulating inflammatory responses, making them attractive targets for therapeutic interventions in diseases characterized by dysregulated immune activity, such as autoimmune disorders and cancer. By investigating the recombinant forms of JAML and AMICA, researchers aim to dissect their binding affinities, signaling pathways, and interactions with other cellular partners, thus contributing to the development of novel strategies for manipulating immune responses for better disease management. The production of these recombinant proteins allows for detailed biochemical and biophysical studies, paving the way for future applications in targeted therapies and the enhancement of vaccine efficacy.
