Analytical Data
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基因名
Blm
- Application
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别名
RecQ helicase homolog
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种属
Mouse
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表达系统
E. coli
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标签
N- His & C- MYC
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O88700
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表达区间
684-859aa
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分子量
24.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BLM (Bloom syndrome protein) is a crucial component of the homologous recombination repair pathway, responsible for maintaining genomic stability. Research on BLM has gained significance due to its association with Bloom syndrome, a rare genetic disorder characterized by a heightened predisposition to cancer and other age-related diseases. The BLM protein acts as a helicase, unwinding DNA during replication and repair processes, which is essential for accurate chromosome segregation. Deficiencies or mutations in the BLM gene can lead to increased genomic instability, contributing to cancer development. Understanding the structure, function, and regulation of BLM is vital for elucidating its role in maintaining genomic integrity and its implications in cancer biology. Recent advances in molecular biology and genetic engineering have provided insights into the biochemical properties of BLM and its interactions with other proteins involved in DNA repair. Research in this area not only enhances our understanding of Bloom syndrome but also opens avenues for targeted therapeutic strategies aimed at cancers associated with defective DNA repair mechanisms.
