Analytical Data
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Gene name
CNTNAP1
- Application
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Alternative Names
Neurexin IVNeurexin-4p190
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P78357
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Expression Region
26-356aa
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Molecular Weight
53.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CNTNAP1, or Contactin-associated protein 1, is a cell adhesion molecule primarily expressed in the central nervous system, playing a crucial role in the formation and maintenance of the nodes of Ranvier in myelinated neurons. Its dysfunction has been implicated in various neurological disorders, including idiopathic generalized epilepsy and neurodevelopmental disorders. Recent studies highlight the significance of CNTNAP1 in axonal integrity and neuronal communication, making it a pertinent target for understanding the molecular mechanisms underlying these conditions. The recombinant protein form of CNTNAP1 is particularly valuable for research purposes, as it allows for detailed studies of its structural and functional properties. By expressing and purifying CNTNAP1 in vitro, researchers can investigate its interaction with other proteins and its role in cell signaling pathways. Moreover, the use of recombinant CNTNAP1 in therapeutic models holds promise for developing potential interventions for diseases associated with its dysfunction. The exploration of CNTNAP1’s properties through recombinant technology thus represents a critical avenue for advancing our understanding of its biological significance and potential clinical applications.
