Analytical Data
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Gene name
EDNRB/Endothelin R Type B
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简介
EDNRB/Endothelin R Type B Protein, a non-specific receptor for endothelin 1, 2, and 3, activates a phosphatidylinositol-calcium second messenger system through G proteins. This mechanism underscores its pivotal role in mediating cellular responses initiated by endothelin neuropeptides, emphasizing the versatility of EDNRB in transducing signals for various physiological processes. EDNRB/Endothelin R Type B Protein, Human (HEK293, His) is the recombinant human-derived EDNRB/Endothelin R Type B protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
EDNRB; Endothelin receptor non-selective type; endothelin receptor type B; ETRB
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P24530
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Expression Region
E27-K101
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Protein Length
Extracellular Domain
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Molecular Weight
16-33 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The Endothelin receptor type B (EDNRB) is a G protein-coupled receptor that plays a crucial role in various physiological processes, including vascular function, pigmentation, and neuronal development. Research into EDNRB has gained traction due to its significant implications in several pathophysiological conditions, such as hypertension, congenital disorders, and certain types of cancer. Mutations in the EDNRB gene have been linked to the genetic syndrome known as Hirschsprung disease, which affects intestinal motility. Additionally, EDNRB's involvement in vascular smooth muscle contraction and endothelial cell function positions it as a potential therapeutic target for cardiovascular diseases. Recombinant EDNRB proteins are valuable tools in biomedical research, enabling scientists to explore the receptor's structure-function relationship, signaling pathways, and interaction with various ligands. The production of EDNRB recombinant proteins allows for detailed investigation into their pharmacodynamics, including receptor activation and downstream effects. This research is critical for developing novel interventions aimed at modulating EDNRB activity, which could lead to new treatments for diseases associated with endothelin signaling dysregulation. Thus, the study of EDNRB and its recombinant forms is pivotal in understanding its biological roles and therapeutic potential in human health.
