Analytical Data
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Gene name
CXCR3
- Application
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Alternative Names
CD183; CKR-L2; CMKAR3; GPR9; IP10r; IP10-R; Mig-R; MigR; G Protein-Coupled Receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49682
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Expression Region
Met1~Arg53+Val111~Lys125+Leu190~Arg212+Asp278~Val298
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Molecular Weight
16kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CXCR3 is a chemokine receptor that plays a critical role in the immune response by regulating the migration and activation of various immune cells, particularly T cells. It is involved in the inflammatory processes associated with chronic diseases such as cancer, autoimmune disorders, and viral infections. Extensive research has shown that CXCR3 is activated by specific chemokines, leading to cellular signaling pathways that influence cell survival, proliferation, and function. The recombinant expression of CXCR3 protein has become a vital tool in understanding its biological functions and therapeutic potential. By producing CXCR3 in a laboratory setting, researchers can study its interactions with ligands and other cellular components, elucidate the receptor's role in disease mechanisms, and explore strategies for modulating its activity for therapeutic use. This research has implications for developing targeted therapies that can enhance or inhibit CXCR3 signaling, paving the way for innovative treatment approaches in immune-mediated diseases. Overall, the study of CXCR3 recombinant protein not only contributes to the fundamental knowledge of immune regulation but also holds promise for advancing clinical applications in immunotherapy and personalized medicine.
