Analytical Data
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Gene name
IFIT3
- Application
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Alternative Names
CIG49ISG-60Interferon-induced 60KDA protein ;IFI-60KInterferon-induced protein with tetratricopeptide repeats 4 ;IFIT-4Retinoic acid-induced gene G protein ;P60 ;RIG-G
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14879
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Expression Region
1-490aa
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Molecular Weight
72 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
IFIT3 (Interferon-Inducible Protein 3) is a crucial component of the innate immune response and plays a significant role in host defense against viral infections. As a member of the IFIT protein family, IFIT3 is primarily upregulated in response to interferons, which are signaling proteins released during viral infections. This expression is pivotal for regulating various cellular processes, including translation inhibition of viral RNA, therefore preventing viral replication. Recent studies have highlighted IFIT3's ability to interact with RNA, contributing to the recognition and degradation of viral genetic material. Moreover, research indicates that IFIT3 can modulate inflammatory responses and immune cell functions, making it a potential target for therapeutic interventions. Investigating the structure and function of recombinant IFIT3 proteins has become essential for understanding their mechanism of action and potential in vaccine development and antiviral drug discovery. By producing IFIT3 in recombinant systems, researchers can explore its binding interactions, post-translational modifications, and overall role in immune signaling pathways. This research not only provides insights into the antiviral properties of IFIT3 but also emphasizes its importance in developing novel strategies to combat viral infections, particularly in an era where emerging and re-emerging viruses pose significant public health challenges. As such, the study of recombinant IFIT3 protein continues to be a promising area of research with the potential to enhance our understanding of immune regulation and develop innovative therapeutic approaches.
