Analytical Data
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Gene name
MPV17
- Application
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Alternative Names
Glomerulosclerosis; Mpv17; Mpv17 human homolog of glomerulosclerosis and nephrotic syndrome; MpV17 mitochondrial inner membrane protein; MPV17_HUMAN; MTDPS6; Protein Mpv17; SYM1
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P39210
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Expression Region
1-176aa
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Molecular Weight
35.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MPV17 is a mitochondrial inner membrane protein that has gained significant attention in the field of molecular biology due to its association with various mitochondrial dysfunctions and genetic disorders. Initially identified in studies related to hepatocerebral mitochondrial DNA depletion syndrome (MDDS), MPV17 is crucial for maintaining mitochondrial integrity and function. Research has shown that mutations in the MPV17 gene can lead to severe clinical manifestations, including neurological deficits and liver abnormalities, which highlight its vital role in cellular energy metabolism and mitochondrial homeostasis. The understanding of MPV17's structure and function is essential not only for elucidating the mechanisms underlying mitochondrial diseases but also for developing potential therapeutic strategies. Investigations into MPV17 have focused on its interactions with other mitochondrial proteins, its involvement in nucleotide metabolism, and the signaling pathways that regulate its activity. Given the increasing prevalence of mitochondrial disorders, exploring the biological significance of MPV17 and its potential as a biomarker or therapeutic target represents a promising avenue for future research in mitochondrial genetics and therapy.
