Analytical Data
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Gene name
Pitx3
- Application
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Alternative Names
Homeobox protein PITX3;Paired-like homeodomain transcription factor 3
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Species
Mouse
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O35160
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Expression Region
1-302aa
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Molecular Weight
58.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Pitx3 is a member of the PITX family of transcription factors, playing a crucial role in the development of specific neuronal populations, particularly in the midbrain and the eye. Its gene is essential for the proper differentiation and maintenance of dopaminergic neurons in the substantia nigra, a region significantly implicated in Parkinson's disease. In addition to its neurological functions, Pitx3 is involved in ocular development, influencing the formation of the lens and retina. Recent studies have highlighted its potential as a therapeutic target for neurodegenerative disorders, emphasizing the need for comprehensive understanding of its molecular mechanisms. The production and characterization of recombinant Pitx3 protein can provide valuable insights into its function and interactions within cellular pathways. By studying this protein in a controlled environment, researchers aim to elucidate its role in gene regulation and neuronal health, contributing to the development of strategies for regenerative medicine and neuroprotection. The exploration of Pitx3 also offers opportunities to advance our knowledge in developmental biology and neurobiology, potentially leading to novel interventions for conditions that stem from its dysregulation.
