Analytical Data
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Gene name
SLC1A6
- Application
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Alternative Names
Sodium-dependent glutamate/aspartate transporter Solute carrier family 1 member 6
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P48664
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Expression Region
149-271aa
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Molecular Weight
40.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC1A6, a member of the solute carrier family, is primarily recognized for its role as a high-affinity transporter of neurotransmitters, particularly glutamate and aspartate, across the cellular membrane. This protein is predominantly expressed in the central nervous system and has been implicated in various pathological conditions, including neurodegenerative diseases and psychiatric disorders. Research into SLC1A6 has gained momentum due to its potential as a therapeutic target, as glutamate homeostasis is critical for synaptic function and neuronal health. The reconstitution of SLC1A6 as a recombinant protein allows for the detailed study of its biophysical properties, substrate specificity, and inhibitor interactions. Understanding the structure and function of SLC1A6 can provide insights into the mechanisms underlying neurotransmitter transport and highlight its role in synaptic plasticity and neurotoxicity. Additionally, advancements in cryo-electron microscopy and X-ray crystallography have facilitated the elucidation of the transport mechanism at the molecular level, opening avenues for drug discovery aimed at modulating SLC1A6 activity in various neurological conditions. This growing body of research underscores the significance of SLC1A6 not only as a fundamental transporter but also as a crucial element in potential therapeutic strategies against conditions linked to glutamatergic dysregulation.
