Analytical Data
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Gene name
PGRP-SC2
- Application
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Species
Drosophila melanogaster
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9V4X2
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Expression Region
21-184aa
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Molecular Weight
25.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PGRP-SC2 (Peptidoglycan Recognition Protein-SC2) is a member of the PGRP family, which plays a crucial role in the innate immune response of various organisms, including insects and mammals. These proteins are known to recognize and bind to peptidoglycan, a key component of bacterial cell walls, triggering an immune response. Recent studies have highlighted the importance of PGRP-SC2 in recognizing both Gram-positive and Gram-negative bacteria, activating signaling pathways that lead to the production of antimicrobial peptides and inflammatory cytokines. The exploration of PGRP-SC2's structure and function is particularly significant in understanding its mechanism of action in immune response regulation. Additionally, its role has implications in disease susceptibility and resistance, making it a potential target for therapeutic interventions. Given the rise of antibiotic resistance, understanding the function of PGRP-SC2 could provide insights into alternative strategies for combating bacterial infections. Furthermore, research has revealed that PGRP-SC2 may be involved in modulating responses to various pathogens and can influence the balance between tolerance and immunity. Overall, the study of PGRP-SC2 not only advances our comprehension of innate immunity but also paves the way for developing novel approaches to enhance host defense mechanisms against infections.
