Analytical Data
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Gene name
ADRM1
- Application
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Alternative Names
ADRM1；GP110；Proteasomal ubiquitin receptor ADRM1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q16186
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Expression Region
1-407aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSHMTTSGALFPSLVPGSRGASNKYLVEF RAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGNVEDDLIIF PDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNE YLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAG LGGLGGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTR ATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNV PAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADE IQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEA FAKAMQNNAKPEQKEGDTKDKKDEEEDMSLD
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Molecular Weight
45 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADRM1, also known as Acidic Dipeptidase and Regulator of Mitochondrial Apoptosis 1, is a protein implicated in various cellular processes, including apoptosis, mitochondrial function, and stress responses. The role of ADRM1 in regulating the cellular stress response makes it a significant focus of research, particularly in the context of cancer and neurodegenerative diseases where mitochondrial dysfunction is a hallmark. Studies have shown that ADRM1 contributes to the regulation of proteasomal activity and protein homeostasis, which are crucial for maintaining cellular health. Additionally, its involvement in apoptosis signaling pathways suggests that ADRM1 may serve as a potential therapeutic target. Advances in recombinant protein technology allow for the production and purification of ADRM1, facilitating detailed studies into its structure, function, and interactions within cells. Understanding the functional implications of ADRM1 and its role in disease mechanisms could lead to novel therapeutic strategies aimed at modulating its activity to promote cell survival or induce apoptosis in cancer cells. As a result, the research around ADRM1 recombinant proteins has gained momentum, offering promising insights that bridge the gap between fundamental biology and potential clinical applications.
