Analytical Data
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Gene name
KCNK13
- Application
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Alternative Names
(Tandem pore domain halothane-inhibited potassium channel 1)(THIK-1)
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HB14
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Expression Region
1-408aa
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Molecular Weight
51.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KCNK13, a member of the potassium channel family, encodes a potassium ion channel that plays a crucial role in regulating the membrane potential and excitability of various cell types. Research into KCNK13 has gained significant attention due to its potential implications in both physiological and pathological processes, including neuronal signaling, cardiac function, and the regulation of smooth muscle contraction. Studies have shown that KCNK13 is expressed in several tissues, including the brain, lungs, and muscles, suggesting it has diverse functional roles. Moreover, abnormal function of KCNK13 has been linked to several disease states, such as epilepsy and other neurological disorders, prompting interest in its structure and function. The generation of recombinant KCNK13 protein has enabled researchers to explore its biophysical properties, ion selectivity, and pharmacological modulation, providing insights into its mechanism of action. Understanding KCNK13's function at a molecular level is essential for developing potential therapeutic strategies targeting its dysregulation in various diseases. Thus, the study of KCNK13 recombinant protein serves as a pivotal step in elucidating the broader roles of potassium channels in cellular physiology and their importance in maintaining homeostasis within the body.
