Analytical Data
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基因名
PTP4A3
- Application
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别名
TP;PRL3;Protein tyrosine phosphatase type IVA 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75365
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表达区间
1-173aa
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氨基酸序列
MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
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分子量
19.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTP4A3, also known as protein tyrosine phosphatase 4A3, is a member of the PTP family, which plays a crucial role in regulating various cellular processes through dephosphorylation of tyrosine residues on target proteins. Its expression has been linked to several types of cancer, particularly in the context of cell proliferation, migration, and invasion. Overexpression of PTP4A3 has been associated with tumorigenesis and poor prognosis in various malignancies, making it a potential oncogenic factor. Researchers have focused on understanding the functional mechanisms of PTP4A3 in signaling pathways involved in cancer progression, including its interactions with other cellular proteins and its role in modifying the tumor microenvironment. The study of recombinant PTP4A3 proteins allows for the investigation of its enzymatic activity, regulatory mechanisms, and potential as a therapeutic target. By producing PTP4A3 in a controlled laboratory setting, scientists can conduct detailed biochemical assays and structural studies, paving the way for the development of inhibitors that specifically target PTP4A3's phosphatase activity. This research is critical for unlocking new avenues for cancer treatment and enhancing our understanding of the molecular underpinnings of oncogenesis. As such, PTP4A3 has emerged as an important focus in the field of cancer research, driving efforts to elucidate its role in tumor biology and therapeutic strategies.












