Analytical Data
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基因名
FAM175B
- Application
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别名
Abraxas brother protein 1;Protein FAM175B
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15018
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表达区间
1-415aa
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分子量
73.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FAM175B, also known as ABRAXAS2, is a protein that has garnered significant attention in recent years due to its potential roles in various biological processes, including DNA damage repair and the modulation of cellular responses to stress. This protein is a part of the BRCA1-A complex, which is critical for the repair of double-strand breaks in DNA through homologous recombination. Mutations and dysregulation of FAM175B have been implicated in various cancers, highlighting the importance of understanding its function and interactions. Research has shown that FAM175B is involved in the recruitment of essential repair proteins to sites of DNA damage, making it a key player in maintaining genomic stability. As such, studies on recombinant FAM175B protein aim to elucidate its structural and functional properties, facilitate the exploration of its mechanisms in DNA repair pathways, and assess its potential as a therapeutic target. Moreover, the generation of recombinant FAM175B can lead to insights into its interactions with other proteins and its role in cellular signaling pathways related to oncogenesis. This growing body of research underscores the relevance of FAM175B not only in fundamental biology but also in the development of cancer therapies, as a better understanding of its function may contribute to novel strategies for treating malignancies associated with its aberrations.
