Recombinant Human ANTXR2 Protein，His

ANTXR2, or Anthrax Toxin Receptor 2, is a type I membrane protein known for its role in mediating cellular responses to anthrax toxin components. Its expression is particularly evident in various tissues, including the heart, lung, and brain, suggesting a potential involvement in distinct physiological processes. Researchers have identified ANTXR2 as a critical factor in the uptake of anthrax toxins, specifically protective antigen (PA), which complexes with lethal factor (LF) or edema factor (EF) to facilitate cellular entry and subsequent cytotoxic effects. Beyond its association with anthrax, ANTXR2 has attracted attention due to its implications in cancer biology, where it may influence tumor growth and metastasis. Studies have demonstrated that ANTXR2 can be overexpressed in certain cancer types, leading to increased cell proliferation and survival. This dual role has prompted investigations into the pathways regulated by ANTXR2, aiming to ascertain its potential as a therapeutic target. Moreover, recombinant ANTXR2 proteins have been developed for various applications, including vaccine research and drug delivery systems. Research continues to explore the structural properties of ANTXR2 and its interactions with ligands, providing insights that could enhance our understanding of toxin-mediated pathogenesis and pave the way for novel therapeutic interventions in diseases associated with its dysregulation. Thus, the study of ANTXR2 not only sheds light on anthrax toxicity mechanisms but also opens pathways for innovative cancer treatment strategies.