Analytical Data
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Gene name
ANTXR2
- Application
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Alternative Names
ANTXR2；CMG2；Anthrax toxin receptor 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H0R4
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Expression Region
34-317aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSQEQPSCR RAFDLYFVLD KSGSVANNWI EIYNFVQQLA ERFVSPEMRL SFIVFSSQAT IILPLTGDRG KISKGLEDLK RVSPVGETYI HEGLKLANEQ IQKAGGLKTS SIIIALTDGK LDGLVPSYAE KEAKISRSLG ASVYCVGVLD FEQAQLERIA DSKEQVFPVK GGFQALKGII NSILAQSCTE ILELQPSSVC VGEEFQIVLS GRGFMLGSRN GSVLCTYTVN ETYTTSVKPV SVQLNSMLCP APILNKAGET LDVSVSFNGG KSVISGSLIV TATECSN
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Molecular Weight
33 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ANTXR2, or Anthrax Toxin Receptor 2, is a type I membrane protein known for its role in mediating cellular responses to anthrax toxin components. Its expression is particularly evident in various tissues, including the heart, lung, and brain, suggesting a potential involvement in distinct physiological processes. Researchers have identified ANTXR2 as a critical factor in the uptake of anthrax toxins, specifically protective antigen (PA), which complexes with lethal factor (LF) or edema factor (EF) to facilitate cellular entry and subsequent cytotoxic effects. Beyond its association with anthrax, ANTXR2 has attracted attention due to its implications in cancer biology, where it may influence tumor growth and metastasis. Studies have demonstrated that ANTXR2 can be overexpressed in certain cancer types, leading to increased cell proliferation and survival. This dual role has prompted investigations into the pathways regulated by ANTXR2, aiming to ascertain its potential as a therapeutic target. Moreover, recombinant ANTXR2 proteins have been developed for various applications, including vaccine research and drug delivery systems. Research continues to explore the structural properties of ANTXR2 and its interactions with ligands, providing insights that could enhance our understanding of toxin-mediated pathogenesis and pave the way for novel therapeutic interventions in diseases associated with its dysregulation. Thus, the study of ANTXR2 not only sheds light on anthrax toxicity mechanisms but also opens pathways for innovative cancer treatment strategies.
